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Updated: Jan 12, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Engineered immune-driven theranostics for clinical cardiology.

Jing-Ben Zheng¹, Xiao-Ye Li¹, Ji-Min Zhu²

¹Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.

Military Medical Research

|November 4, 2025

Summary

Nanotechnology enables precision immunotherapy for cardiovascular diseases (CVDs) by regulating immune responses and imaging cell activity. This approach halts disease progression and prevents further cardiovascular events through personalized interventions.

Keywords:

Cardiovascular diseases Immune therapy Inflammatory regulation Medical imaging Nanotheranostics

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Area of Science:

Cardiovascular Diseases
Immunotherapy
Nanotechnology
Precision Medicine

Background:

Cardiovascular diseases (CVDs) involve complex immune-inflammatory responses.
Effective management requires integrated strategies for localized and systemic disease.
Immune cell activity plays a critical role in CVD pathogenesis.

Purpose of the Study:

To review advances in nanomaterial-based immunomodulation for CVDs.
To explore nanoplatforms for regulating and imaging immune cells in cardiovascular lesions.
To highlight the potential of nanotheranostics in precision cardiovascular medicine.

Main Methods:

Summarizing recent research on nanomaterial-based immunomodulation strategies.
Discussing mechanisms of immune regulation and enhanced imaging by nanoplatforms.
Reviewing therapeutic applications in atherosclerosis, myocardial infarction, stroke, aneurysm, and myocarditis.

Main Results:

Nanotechnology-based theranostic platforms offer dual regulation and imaging of immune cells.
These systems can halt disease progression at pathological sites.
Dynamic visualization facilitates adaptive, personalized therapeutic interventions.

Conclusions:

Integrated nanotheranostic paradigms are crucial for next-generation cardiovascular precision medicine.
Nanomaterials provide a robust foundation for modulating immune responses in CVDs.
This approach promises reduced secondary cardiovascular events and improved patient outcomes.