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Updated: Jan 12, 2026

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Published on: March 18, 2020
Management of the child with primary immunodeficiency
Heather K Lehman1, Anushka Khaira, Simranjit Kaur
1Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Inborn errors of immunity (IEI) require comprehensive management for both infectious and noninfectious complications. Advances in definitive therapies improve outcomes for patients with these complex genetic immune disorders.
Area of Science:
- Immunology
- Genetics
- Pediatrics
Background:
- Inborn errors of immunity (IEI) encompass over 550 genetic disorders affecting immune function.
- Immune dysregulation is a key feature of many IEI.
- Historically, focus was on infectious complications, but noninfectious issues are increasingly recognized.
Purpose of the Study:
- To provide an updated review on the monitoring, prevention, and treatment of complications in immune deficiencies.
- To highlight the evolving understanding and management of inborn errors of immunity (IEI).
Main Methods:
- Literature review of recent advances in the field of inborn errors of immunity.
- Synthesis of current knowledge on infectious and noninfectious complications.
- Analysis of emerging therapeutic strategies.
Main Results:
- Significant progress has been made in definitive therapies like hematopoietic stem cell transplant, gene therapy, and gene editing for cellular and phagocytic immune defects.
- Effective management necessitates addressing both infectious and noninfectious complications.
- Over 550 distinct IEI have been identified.
Conclusions:
- Comprehensive management of IEI requires a multidisciplinary approach.
- Monitoring, prevention, and treatment strategies must encompass both infectious and noninfectious sequelae.
- Advances in therapy offer improved outcomes for patients with IEI.
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