Review of Polysaccharides/Proteins Combine With Metals: A New Strategy for Wound Healing Therapy

Wound dressing is crucial for managing wound healing, protecting wounds from the environment, and accelerating the healing process. Recently, wound dressing is evolving from traditional to modern-interactive design. The main problem with traditional wound dressings is their limited effectiveness, which hinders optimal wound therapy. Wound dressings can be developed into modern wound dressings (film, sponge, injectable hydrogel, and nanofiber). They can be fabricated using natural polymers, such as chitosan, alginate, cellulose, gelatin, and collagen, combined with metals. Natural polymers, known as biopolymers, offer beneficial properties for wound healing, including bioactivity, biocompatibility, and biodegradability. Additionally, metals like silver, copper, cerium, and zinc also exhibit potential pharmacological activity in the medical field. The fabrication of these materials holds significant potential for addressing wound healing challenges. This article discusses the development of natural polymer/metal-based scaffolds and their potential for wound healing management therapy. This innovative approach stands to offer an alternative to the existing strategies and enhance the effectiveness of wound healing management.