Related Experiment Video

Updated: Jan 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

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Pathogenesis, diagnosis and management of chronic hepatitis B related liver fibrosis

Mehmet A Kosekli1, Gulali Aktas2

  • 1Department of Gastroenterology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Türkiye - kosekli@gmail.com.

Minerva Gastroenterology
|November 5, 2025
PubMed

Insights

Chronic hepatitis B (CHB) causes liver fibrosis, a key factor in disease progression. This review details CHB fibrosis mechanisms, diagnosis, and management strategies for better patient outcomes.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Virology

Background:

  • Chronic hepatitis B (CHB) is a major global cause of liver disease.
  • Liver fibrosis is a critical factor influencing long-term prognosis in CHB patients.

Purpose of the Study:

  • To provide a comprehensive review of CHB-related liver fibrosis.
  • To examine the pathogenesis, diagnostic methods, and management strategies for CHB-associated liver fibrosis.

Main Methods:

  • Narrative review synthesizing current evidence.
  • Examination of viral replication, immune response, and hepatic stellate cell activation in fibrosis.
  • Evaluation of diagnostic techniques including non-invasive biomarkers, imaging, and liver biopsy.

Main Results:

  • Detailed mechanisms of CHB fibrosis pathogenesis are outlined.
  • Current diagnostic tools are assessed for clinical utility and accuracy.
  • Antiviral therapies and emerging antifibrotic agents for management are discussed.

Conclusions:

  • Early detection and tailored treatment are crucial for improving patient outcomes in CHB fibrosis.
  • The review highlights evolving insights and persistent challenges in managing CHB-related liver fibrosis.

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