Related Experiment Video
Updated: Jan 12, 2026
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Beyond inflammation: what drives the self-perpetuating cycle of fibrosis in IBD?
Yutong Wei1, Zhou Zhou2, Shiyu Xiao2,3
1School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Abstract:
Intestinal fibrosis is a major complication of inflammatory bowel disease (IBD). While inflammation is a prerequisite for initiating fibrosis, it does not fully explain its progression, which often continues despite effective anti-inflammatory treatment. This suggests that fibrotic mechanisms evolve from an inflammation-dependent priming phase to a self-perpetuating phase that can operate independently of ongoing inflammation. While the former has been widely studied, the latter remains underexplored. In this context, this review summarizes the current evidence on the self-perpetuating mechanisms driving fibrosis in IBD, even after inflammation resolves. We delve into key drivers such as genetic predisposition, extracellular matrix microenvironment, creeping fat, and metabolic reprogramming. The aim is to enhance understanding of this self-sustaining cycle and encourage further research to advance treatment strategies for IBD-related fibrosis.
More Related Videos
05:08A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
10:21Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
Published on: September 12, 2019
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF