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Updated: Jan 12, 2026
05:56
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
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Inflammation and Immune Pathways in Myopia: An Overview on Pathomechanisms and Treatment Prospects
Jing Zhang1, Koju Kamoi2, Yuan Zong1
1Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Clinical Reviews in Allergy & Immunology
|November 5, 2025
Summary
Inflammation contributes to myopia progression by degrading eye tissues. Anti-inflammatory drugs show promise in experimental models, suggesting new disease-modifying strategies for myopia management.
Area of Science:
- Ophthalmology
- Immunology
- Pathology
Background:
- Myopia is a global health issue with increasing prevalence and serious complications.
- While genetics and environment are known factors, inflammation's role in myopia progression is increasingly recognized.
Purpose of the Study:
- To explore the pathological link between inflammation and myopia progression.
- To review the potential of anti-inflammatory agents in managing myopia.
Main Methods:
- Review of epidemiological studies linking inflammation and myopia.
- Analysis of the molecular mechanisms of inflammation-induced ocular changes.
- Evaluation of experimental data on anti-inflammatory agents in myopia models.
Main Results:
- Inflammation upregulates pro-inflammatory cytokines and matrix metalloproteinase-2, accelerating extracellular matrix degradation and scleral remodeling, leading to axial elongation.
- High myopia can create a self-perpetuating inflammatory loop.
- Anti-inflammatory agents like diacerein, resveratrol, and lactoferrin show therapeutic potential in preclinical studies.
Conclusions:
- Inflammation is a key factor in myopia progression and associated complications.
- Targeting inflammatory pathways offers a promising avenue for disease-modifying myopia management strategies.
- Further clinical validation of anti-inflammatory agents is necessary.
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