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Cytotoxic Chaetoglobosins From a Soil-derived Chaetomium sp
Jie Xu1, Yanfang Yang2, Qianqian Li3
1Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Abstract:
Ten chaetoglobosin alkaloids were isolated from the fermentation culture of a soil-derived fungus, Chaetomium sp., and their structures with absolute configurations were characterized by spectroscopic methods including high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), X-ray diffraction analysis, and electronic circular dichroism, as well as comparison with literature data. Among them, three compounds (1-3) have not been described previously, and compound 8 is reported for the first time as a new natural product. A preliminary cytostatic screening revealed good inhibitory activity for 1, 6, and 8 against the A549 cell line (lung), and for 1, 2, 4, 6, and 8 against the MDA-MB231 cell line (breast). Further exploration demonstrated that compound 8 exerted in vitro antitumor activity by inducing significant apoptosis and S-phase cycle arrest, as well as blocking the migration and invasion of MDA-MB231 cells.
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