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Updated: Jan 12, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Hierarchically Structured Aquatic Collagen-Hydroxyapatite Matrices for Targeted Alveolar Ridge Regeneration.

Huaqi Cao1, Yuanjin Zeng1, Jun Kit Wang2

  • 1China-Singapore International Joint Research Institute (CSIJRI), China Singapore Guangzhou Knowledge City Huangpu, Guangzhou, 510555, P. R. China.

Advanced Healthcare Materials
|November 6, 2025
PubMed
Summary
This summary is machine-generated.

AquaGraft, a novel bone graft from bullfrog collagen and fish hydroxyapatite, effectively preserves alveolar ridges post-extraction. This bioactive material resorbs completely, promoting vascularization and new bone formation comparable to traditional grafts.

Keywords:
alveolar ridge preservation (ARP)bioactive materialsbone regenerationcollagenhydroxyapatite

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Implantology

Background:

  • Alveolar ridge preservation (ARP) is crucial for dental implant success.
  • Current bone grafts, like deproteinized bovine bone mineral, have limitations in resorption and bioactivity.
  • A need exists for advanced bone graft materials that enhance regeneration and integration.

Purpose of the Study:

  • To introduce and evaluate AquaGraft, a novel, fully resorbable bone graft composite.
  • To compare AquaGraft's hemostatic, resorption, and bone regeneration properties against a commercial xenograft (Bio-Oss® Collagen).
  • To assess AquaGraft's potential as a bioactive scaffold for alveolar ridge preservation.

Main Methods:

  • AquaGraft, a composite of bullfrog collagen and fish-scale hydroxyapatite, was engineered into a porous structure.
  • Ex vivo whole-blood hemostasis assays were performed.
  • Canine models were used to evaluate ridge preservation, bone regeneration, and resorption over 16 weeks.
  • Quantitative imaging analyzed buccal ridge preservation and new bone formation.

Main Results:

  • AquaGraft demonstrated significantly faster clot formation than Bio-Oss® Collagen.
  • Complete resorption of AquaGraft was observed within 16 weeks in canine models.
  • AquaGraft supported continuous bone bridging with enhanced 3D vascular network formation.
  • Comparable buccal ridge preservation and new bone formation were achieved with AquaGraft versus Bio-Oss® Collagen.

Conclusions:

  • AquaGraft is a promising, fully resorbable, and bioactive bone graft material.
  • Its unique composition and structure facilitate efficient bone regeneration and vascularization.
  • AquaGraft offers a viable alternative for alveolar ridge preservation, potentially improving long-term implant integration.