Related Experiment Video
Updated: Jan 6, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Metabolic profiles mediate insomnia-related cognitive impairments in schizophrenia: a large-scale study
Linxuan Wang1,2, Yanzhe Li1,2, Yanping Wang3
1Department of Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China.
Background:
Insomnia has a significant impact on metabolic changes and cognitive impairments in schizophrenia (SCZ) patients. This study aimed to explore these relationships in SCZ patients.
Methods:
A total of 609 SCZ patients were recruited. Insomnia was assessed using a self-reported questionnaire with three questions. The psychopathology and cognitive functioning were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Repeated Battery for Assessment of Neuropsychological Status (RBANS), respectively.
Results:
SCZ patients with insomnia exhibited lower diastolic blood pressure (DBP), higher total cholesterol (TC) and poorer cognitive performance in language, attention, delayed memory and RBANS total score compared to those without insomnia (all p < 0.05). In SCZ patients with insomnia, fasting glucose contributed to immediate memory and RBANS total scores (all p < 0.05). In SCZ patients without insomnia, fasting glucose contributed to immediate memory (Beta = 0.223, t = 4.462, p < 0.001), triglycerides and DBP to visuospatial/constructional (all p < 0.05), and triglycerides to delayed memory (Beta = 0.118, t = 2.060, p = 0.040).
Conclusions:
Our findings underscore the importance of addressing both metabolic and cognitive factors in SCZ patients with insomnia.
More Related Videos
07:04A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
Published on: August 19, 2018
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
Related Concept Videos
Management of Insomnia
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Insomnia
Multiple factors contribute...
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...