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Visual Outcomes of Children With Primary Congenital Glaucoma Receiving Different Refractive Corrections: The

Jinyun Jiang1, Yin Hu1, Yingting Zhu1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

JAMA Ophthalmology
|November 6, 2025
PubMed

Insights

Rigid gas-permeable contact lenses (RGPCLs) significantly improved visual acuity and contrast sensitivity in children post-primary congenital glaucoma (PCG) surgery compared to spectacles. RGPCLs are recommended for PCG rehabilitation, especially for those with poor spectacle response.

Area of Science:

  • Ophthalmology
  • Pediatric Eye Care
  • Glaucoma Research

Background:

  • Primary congenital glaucoma (PCG) surgery often results in residual visual impairment in children.
  • Effective visual rehabilitation strategies are crucial for improving outcomes in these patients.

Purpose of the Study:

  • To compare the efficacy of rigid gas-permeable contact lenses (RGPCLs) versus continued spectacle wear for visual rehabilitation in children following PCG surgery.

Main Methods:

  • A randomized clinical trial involving 56 children (aged 4-15 years) with surgically managed PCG and poor spectacle response.
  • Participants were randomized to wear RGPCLs (n=29) or spectacles (n=27) for 12 months, with standardized amblyopia patching.
  • Primary outcome was the change in best-corrected visual acuity (BCVA) in the worse eye at 12 months; secondary outcomes included contrast sensitivity and near stereoacuity.

Main Results:

  • The RGPCL group showed significantly greater improvement in BCVA compared to the spectacles group (0.31 vs 0.12 logMAR, P=.03).
  • More participants in the RGPCL group achieved a 2-line BCVA improvement (62.5% vs 37.5%, P=.01).
  • RGPCLs also led to greater improvements in contrast sensitivity and near stereoacuity (P=.04 and P=.001, respectively), with no serious adverse events.

Conclusions:

  • Rigid gas-permeable contact lenses offer superior visual acuity and contrast sensitivity benefits compared to spectacles for children after PCG surgery.
  • RGPCLs are a recommended option for visual rehabilitation in children with PCG, particularly those with poor spectacle response or worse baseline visual acuity.
Abstract

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