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Improvement of Postoperative Visual Outcomes in Children With Primary Congenital Glaucoma

Jinyun Jiang1, Yin Hu, Yingting Zhu

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Eye & Contact Lens
|December 29, 2025
PubMed

Insights

Corneal rigid gas permeable contact lenses (RGPCLs) significantly improved vision and contrast sensitivity in children with primary congenital glaucoma (PCG) compared to spectacles. RGPCLs offer a promising option for visual rehabilitation in this patient group.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Optometry

Background:

  • Primary congenital glaucoma (PCG) often leads to visual impairment.
  • Effective visual rehabilitation strategies are crucial for children with PCG.
  • Spectacles are a common method for vision correction in this population.

Purpose of the Study:

  • To compare the vision improvement provided by corneal rigid gas permeable contact lenses (RGPCLs) versus spectacles in children with PCG.
  • To evaluate the impact of RGPCLs on visual acuity and contrast sensitivity.

Main Methods:

  • Cross-sectional analysis of baseline data from the CLEVR-PCG randomized trial.
  • Included 51 eyes from 29 children (mean age 7.41±2.51 years) with controlled intraocular pressure.
  • Compared best spectacle-corrected visual acuity (BSCVA), best RGPCL-corrected visual acuity (BCLVA), and contrast sensitivity function (CSF).

Main Results:

  • BCLVA was significantly better than BSCVA (0.30 vs. 0.40 LogMAR).
  • CSF with RGPCLs was superior to spectacles, with higher CSF acuity (0.94 vs. 0.83) and area under the curve (0.68 vs. 0.51).
  • Greater myopic spherical equivalent correlated with improved BCVA and CSF acuity.

Conclusions:

  • Corneal rigid gas permeable contact lenses (RGPCLs) provide immediate vision improvement in children with primary congenital glaucoma (PCG).
  • RGPCLs demonstrate potential as an effective tool for visual rehabilitation in children with PCG.
  • These findings support the consideration of RGPCLs for managing visual deficits in PCG.
Abstract

Keywords:
Primary congenital glaucomaRigid gas permeable contact lensesVisual outcomes

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