Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

502
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
502
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

623
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
623
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

422
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
422
Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

557
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
557
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

506
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
506
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

285
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
285

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of naloxone by EMS for opioid-associated out-of-hospital cardiac arrest and associated patient-centered outcomes: A systematic review.

PloS one·2026
Same author

Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.

JAMA·2026
Same author

Prehospital Application of Pelvic Binders for Suspected Pelvic Ring Injuries: A Retrospective Cohort Study.

Prehospital emergency care·2026
Same author

Best practices on blood and blood products for a prehospital hemorrhage protocol: consensus from the 2025 Canadian prehospital transfusion summit.

Scandinavian journal of trauma, resuscitation and emergency medicine·2026
Same author

Prehospital Use of Non-Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial.

Acta anaesthesiologica Scandinavica·2026
Same author

Anticipatory charging of the defibrillator: a systematic review.

Resuscitation plus·2026
Same journal

Cardiogenic shock - toward phenotype-directed, precision management.

Current opinion in critical care·2026
Same journal

The future of critical care nutrition: from calorie counting to precision personalized metabolism therapy.

Current opinion in critical care·2026
Same journal

Editorial introduction.

Current opinion in critical care·2026
Same journal

Generative artificial intelligence for outcome prediction in critical care: the future is now?

Current opinion in critical care·2026
Same journal

Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy.

Current opinion in critical care·2026
Same journal

Multinational collaborations in critical care research: feasible and useful?

Current opinion in critical care·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.8K

Double sequential defibrillation: is it ready for prime time?

Bertram Lahn Kirkegaard1,2, Sheldon Cheskes3,4,5,6, Lars W Andersen1,2,7

  • 1Prehospital Emergency Medical Services, Central Denmark Region.

Current Opinion in Critical Care
|November 6, 2025
PubMed
Summary
This summary is machine-generated.

Double sequential external defibrillation (DSED) shows promise for refractory ventricular fibrillation, improving patient outcomes. However, further research is needed to fully understand its mechanisms and clinical implementation.

Keywords:
cardiac arrestdefibrillationdouble sequential defibrillationresuscitation

More Related Videos

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

16.3K
Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.3K

Related Experiment Videos

Last Updated: Jan 12, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.8K
A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

16.3K
Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.3K

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Critical Care

Background:

  • Refractory ventricular fibrillation (VF) carries a high mortality rate.
  • Current treatments for refractory VF are limited to standard defibrillation and cardiopulmonary resuscitation.
  • Double sequential external defibrillation (DSED) is an emerging strategy for patients unresponsive to initial defibrillation attempts.

Purpose of the Study:

  • To review the evidence supporting and opposing the clinical readiness of DSED for refractory VF.
  • To discuss the controversies surrounding the implementation of DSED into clinical practice.

Main Methods:

  • Review of existing literature and clinical trial data on DSED.
  • Presentation of arguments for and against the immediate clinical adoption of DSED.
  • Discussion of findings from the Double Sequential External Defibrillation for Refractory Ventricular Fibrillation (DOSE VF) trial.

Main Results:

  • The DOSE VF trial indicated improved outcomes in patients with refractory VF treated with DSED.
  • Unanswered questions persist regarding the precise mechanisms of DSED's efficacy.
  • Logistical challenges for implementing DSED in clinical settings require further investigation.

Conclusions:

  • DSED presents a potentially valuable strategy for refractory VF.
  • Controversies remain regarding its immediate integration into standard care.
  • Ongoing research aims to clarify the utility and optimal application of DSED.