Missing the needle in the haystack: diagnostic errors in neurological emergencies within Canadian emergency...

Timely diagnosis of neurological emergencies in the emergency department (ED) remains a critical skill for physicians. Errors in diagnosing neurological conditions can lead to severe patient harm, including permanent disability or death. Conversely, over-investigation may contribute to unnecessary imaging, increased healthcare costs, and reduced departmental efficiency. Understanding the nature and frequency of these diagnostic errors is essential to improving clinical practice and patient safety. The primary objective of this study was to describe the nature of diagnostic errors for neurologic emergencies in the ED.

This study conducted a five-year descriptive analysis of closed medicolegal cases from the Canadian Medical Protective Association (CMPA) database involving missed or delayed neurological diagnoses in Canadian EDs between January 2019 and December 2023. Cases were reviewed for patient demographics, primary neurological condition, provider type, patient-reported concerns, and expert reviewer commentary. Allegations and identified deficiencies were coded thematically and analyzed for common patterns and clinical pitfalls.

A total of 143 cases met inclusion criteria. The most frequently missed diagnoses were cerebral infarcts (34%), traumatic intracranial injuries (22%), and central nervous system infections (15%). Cauda equina syndrome accounted for 8% of cases. Patient concerns frequently mirrored expert peer review findings, which identified deficient assessment, failure to consider key differential diagnoses, and inadequate diagnostic testing as the top contributing factors. Many cases involved atypical or non-specific presentations that may have led providers to prematurely rule out serious pathology.

Diagnostic errors in neurological emergencies remain an important contributor to patient harm and medico-legal risk in Canadian EDs. A better understanding of the factors that contribute to these diagnostic errors can support physicians in improving their clinical reasoning and documentation. These insights may ultimately empower Canadian emergency physicians to refine their diagnostic approach and enhance patient outcomes in both emergency and non-emergency settings.