Related Experiment Video
Updated: Jan 12, 2026
Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Mesenchymal Stem Cell Transplantation for Osteogenesis Imperfecta Patients: A Systematic Review
Mohaddese Mohaddesi Khorasani1,2,3,4, Mohammad Hossein Ebrahimzadeh1,2,3,5, Mohsen Dehghani6
1Orthopedics Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
None:
The following systematic review provides an evaluation of the effectiveness of mesenchymal stem cell (MSC) transplantation in the treatment of osteogenesis imperfecta (OI). After reviewing 40 studies, 9 human clinical studies that included case reports or case series were included and resulted in a total of 12 patients with OI. Five studies documented an increase in total body bone mineral (TBBM) content, whereas four studies observed a reduction in fracture rates post-transplantation. Moreover, noticeable improvements in children's growth were recorded. Although both BMSCs and human fetal MSCs (hfMSCs) were found to be effective, studies involving BMSCs were rated higher in terms of methodological quality. Both BMSCs and hfMSCs demonstrated significant improvements in TBBM, growth rates, and fracture reduction, with BMSC studies scoring higher in methodological quality. Future randomized clinical trials with longer follow-ups are necessary.
