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Development of a Clinically Relevant Rabbit Model of Acute Laryngeal Injury.

Ryan Stepp1, Naushin Ali1, Areli A Rodriguez2

  • 1Department of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.

Laryngoscope Investigative Otolaryngology
|November 7, 2025
PubMed
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This summary is machine-generated.

This study developed a rabbit model for acute laryngeal injury (ALgI) caused by endotracheal tubes. The model effectively replicates fibrosis and inflammation, aiding research into ALgI and potential treatments.

Area of Science:

  • Otolaryngology
  • Wound Healing Research
  • Animal Modeling

Background:

  • Acute laryngeal injury (ALgI) results from endotracheal tube pressure, causing fibrosis, inflammation, airway obstruction, and voice/swallowing issues.
  • Existing research lacks a reliable animal model to study ALgI's acute wound process and pathophysiology.

Purpose of the Study:

  • To establish a reproducible animal model of acute laryngeal injury (ALgI).
  • To investigate the pathophysiology of ALgI.
  • To create a platform for evaluating therapeutic interventions for ALgI.

Main Methods:

  • Developed an ALgI model in New Zealand White rabbits.
  • Utilized precise mucosal stripping of the posterior larynx followed by intubation with an oversized endotracheal tube for 1 hour.
Keywords:
acute laryngeal injuryairway stenosisanimal modelfibrosislaryngeal trauma

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  • Performed laryngoscopy and laryngeal harvest 2 weeks post-injury for histological and immunofluorescence analysis.

    • Main Results:

    • Injured rabbits showed significantly increased posterior glottic thickness and collagen content.
    • Collagen analysis revealed a shift towards Type III Collagen and reduced Type I Collagen, indicative of the proliferative wound healing phase.
    • Increased collagen fiber alignment suggested early scar formation in the injured larynx.

    Conclusions:

    • The developed rabbit model reliably reproduces acute laryngeal injury.
    • This model serves as a robust platform for studying ALgI pathogenesis.
    • The model is suitable for evaluating therapeutic strategies for ALgI management.