Identification of Risk Factors in Postoperative Urinary Dysfunction for Rectal Gastrointestinal Stromal Tumors

Area of Science:

• Gastroenterology
• Surgical Oncology
• Urology

Background:

• Rectal gastrointestinal stromal tumors (GISTs) require surgical management focusing on curative resection and organ preservation.
• Postoperative quality of life, particularly urinary function, is a significant concern for patients undergoing rectal GIST surgery.
• Previous studies indicate a high incidence of urinary dysfunction following surgical resection of rectal GISTs.

Purpose of the Study:

• To determine the incidence of postoperative urinary dysfunction after rectal GIST surgery.
• To identify preoperative risk factors associated with urinary dysfunction in patients treated for rectal GISTs.

Main Methods:

• Retrospective study including 45 patients who underwent rectal GIST surgery between January 2008 and March 2022.
• Tumor size assessed by MRI; postoperative urinary dysfunction defined by catheterization needs at discharge.
• Univariable and multivariable analyses performed to identify risk factors.

Main Results:

• The incidence of postoperative urinary dysfunction was 24.4%.
• Univariable analysis identified tumor size ≥50mm and preoperative targeted therapy as risk factors.
• Multivariable analysis revealed male sex (OR=8.2) and tumor size ≥50mm (OR=9.0) as independent preoperative risk factors.

Conclusions:

• Postoperative urinary dysfunction occurs in 24.4% of patients following rectal GIST surgery.
• Preoperative risk factors for urinary dysfunction include male sex and tumor size ≥50mm.
• These findings aid in preoperative risk assessment and patient counseling for rectal GIST management.