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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

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Hemorheology Reference Intervals in Healthy Dogs Using the MIZAR Analyzer.

Francisco O Conrado¹, Cynthia Leveille-Webster², Noa Berlin²

¹Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Veterinary Clinical Pathology

|November 7, 2025

Summary

This summary is machine-generated.

This study establishes reference intervals for canine hemorheology, highlighting the importance of adhering to ASVCP guidelines for accurate red blood cell (RBC) rheology assessments in veterinary diagnostics.

Keywords:

erythrocyte aggregation hematology hemodynamics red blood cell deformability rheology

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Area of Science:

Veterinary Hematology
Biophysics
Diagnostic Medicine

Background:

Hemorheology, the study of blood flow properties, is underutilized in veterinary medicine.
Red blood cell (RBC) rheology assessment offers potential for diagnosing and monitoring canine diseases.
Establishing species-specific reference intervals (RIs) is crucial for clinical application.

Purpose of the Study:

To determine hemorheological reference intervals (RIs) in healthy dogs.
To compare RIs generated at 620 nm versus 800 nm wavelengths.
To evaluate the impact of adhering to ASVCP guidelines on RI generation.

Main Methods:

Collected whole blood from 42 healthy dogs in EDTA tubes.
Analyzed 13 hemorheological parameters using the MIZAR Analyzer.
Calculated RIs using parametric/non-parametric methods, with and without ASVCP guideline adherence, at 620 nm and 800 nm.

Main Results:

Established RIs for 13 hemorheological parameters at both wavelengths.
Observed minimal differences for 5/13 parameters between wavelengths; others shifted higher at 800 nm.
Found ASVCP guideline adherence critical for 6/13 parameters, yielding clinically unsuitable results otherwise.

Conclusions:

Defined specific RIs for canine hemorheology at 620 nm and 800 nm.
Emphasized the necessity of following ASVCP guidelines for reliable veterinary hemorheology assessments.