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Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional
Suparuj Lueangarun1,2, Patrick Po-Han Huang3, Wan-Yi Chou4
1Department of Aesthetic Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand.
Journal of Cosmetic Dermatology
|November 7, 2025
Summary
Exosome therapy shows promise for reversing gray hair by restoring pigment. Factors like shorter graying duration and androgenetic alopecia may predict successful hair repigmentation outcomes.
Area of Science:
- Regenerative medicine
- Dermatology
- Aesthetics
Background:
- Hair graying is linked to melanocyte stem cell depletion.
- Exosome-based therapies are emerging regenerative strategies for hair pigmentation restoration.
Purpose of the Study:
- To evaluate clinical outcomes of exosome therapy for gray hair.
- To identify factors correlating with hair repigmentation.
Main Methods:
- Observational study of 10 patients with gray hair treated with rose stem cell-derived exosomes (RSCEs).
- Assessed hair repigmentation using a standardized scale.
- Analyzed correlations between clinical variables and treatment response.
Main Results:
- Repigmentation observed after ~2.4 sessions, maintained for ~4.7 months.
- 60% of patients showed ≥50% improvement in hair repigmentation.
- Shorter graying duration, presence of androgenetic alopecia (AGA), and moderate baseline severity predicted better outcomes. No adverse events reported.
Conclusions:
- Exosome therapy is a safe and promising treatment for hair repigmentation.
- AGA, shorter graying duration, and moderate severity may indicate better treatment response.
- Further controlled studies are needed to standardize protocols.
