Preliminary Insights From a Split-Face Study on Skin Quality Changes After Needling Radiofrequency With or Without a...

Area of Science:

• Dermatology and Aesthetic Medicine
• Regenerative Medicine
• Biotechnology

Background:

• Radiofrequency microneedling (RFM) is a procedure for dermal remodeling.
• Rose stem cell-derived exosomes (RSCEs) have regenerative properties but limited skin penetration.
• Combining RFM with RSCEs may overcome penetration limitations and enhance therapeutic effects.

Purpose of the Study:

• To evaluate the efficacy of RSCEs applied post-RFM in improving wrinkles, skin texture, and pores.
• To assess the synergistic effects of RSCEs and RFM in Asian patients.

Main Methods:

• A prospective, split-face study involving 6 Asian subjects (Fitzpatrick III-IV).
• One side of the face received RFM alone, while the other received RFM followed by RSCE application.
• Standardized photography and Vectra Sculptor analysis were used for assessment at baseline and at 1, 3, and 6 months.

Main Results:

• The RFM + RSCE side showed significantly greater wrinkle reduction at 1 and 3 months compared to RFM alone.
• Faster early improvement and sustained remodeling were observed with RFM + RSCE, while RFM alone showed rebound worsening.
• Skin texture and pore response varied by skin phenotype, with RSCEs benefiting collagen-deficient skin and RFM alone suiting sebaceous-dominant skin.

Conclusions:

• Adding RSCEs to RFM may enhance skin quality improvements, including wrinkles, texture, and pores.
• RSCEs appear to act synergistically with RFM, potentially boosting dermal remodeling.
• Further large-scale controlled trials are needed to confirm these findings and identify optimal patient candidates.