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Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation
Naoya Tatsumi1,2, Ariel Tjitropranoto1,2, Alejandro Davila-Pagan1,2
1Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
None:
Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by presenting antigens to prime antigen-specific T cells. Conventional DC (cDC) type 2 cells (cDC2s) are a phenotypically heterogeneous population of DCs highly capable of presenting antigens to CD4+ T cells. Studies found functional differences between different cDC2 subsets in regulating effector CD4+ T helper (Th) cells, but collaboration between different cDC subsets has also been suggested. In this review, we discuss recent advances in understanding the subset-specific role of cDC2s in regulating Th cells.
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