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Updated: Jan 12, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Cobalt-Catalyzed Four-Component Carbonylative Synthesis of γ-Thioesters and γ-Thioamides from Thioethers and Ethylene
Xudong Mao1,2, Le-Cheng Wang1,2, Xiao-Feng Wu1,2
1Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Abstract:
Multicomponent carbonylative reactions have proven to be indispensable for constructing heterocycles and highly functionalized molecular frameworks and represent an attractive strategy for alkene functionalization. Herein, we report a cobalt-catalyzed four-component carbonylation of thioethers and ethylene gas with diverse nucleophiles, affording a series of γ-thioether amides and γ-thioether esters. The reaction features a broad substrate scope, good chemo- and regioselectivity, and excellent functional-group tolerance.
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Esters to Alcohols: Grignard Reaction
The reaction requires two equivalents of the Grignard reagent and introduces two identical alkyl groups, derived from the Grignard reagent, bonded to the hydroxyl-bearing carbon of the alcohol.
The reaction follows the typical nucleophilic acyl substitution mechanism. The Grignard...

