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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Mutations01:35

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Updated: Jan 12, 2026

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Radiation-Induced Skin Injury: Mechanisms, Clinical Manifestations, and Management.

Sahar Dadkhahfar1, Parisa Farokh2, Shadmehr Demehri2

  • 1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Radiation-induced skin injury (RISI) affects many cancer patients. This review details RISI

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Area of Science:

  • Oncology
  • Dermatology
  • Radiotherapy

Background:

  • Radiation-induced skin injury (RISI) is a frequent complication of cancer radiotherapy.
  • It encompasses acute and chronic reactions impacting patient quality of life and treatment outcomes.

Purpose of the Study:

  • To synthesize current knowledge on RISI pathophysiology, clinical and histopathologic features, and management.
  • To emphasize strategies relevant for dermatologists and oncology clinicians.

Main Methods:

  • Literature review synthesizing current understanding of RISI.
  • Emphasis on evidence-based preventive and therapeutic approaches.

Main Results:

  • Acute radiation dermatitis (ARD) affects up to 95% of patients; chronic radiation dermatitis (CRD) affects 5%-15%.
  • Preventive measures (e.g., moisturization, corticosteroids) reduce ARD severity.
  • Treatments (e.g., antimicrobial dressings, lasers, fat grafting) improve CRD outcomes.

Conclusions:

  • Dermatologists play a key role in RISI prevention, diagnosis, and management.
  • A multidisciplinary, evidence-based approach is crucial for reducing morbidity and improving patient quality of life.