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Updated: Jan 12, 2026

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization

Published on: August 18, 2022

Optothermal Ice-Water Interface Management for Cross-Scale Enrichment and Molecular Sensing.

Yuhang Peng¹, Jianxing Zhou¹, Jiajie Chen¹

¹State Key Laboratory of Radio Frequency Heterogeneous Integration, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronics Engineering, Shenzhen University, Shenzhen 518060, China.

|November 7, 2025

Summary

Optothermal ice-water interface management (OIIM) offers a universal, label-free method for analyte enrichment across scales. This technique precisely concentrates diverse molecules and particles, enabling advanced biosensing and nanomaterial applications.

Keywords:

biomolecule enrichment enzyme–cascade reaction ice−water interface nucleic acids optothermal manipulation

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Area of Science:

Interdisciplinary science
Physical chemistry
Nanotechnology

Background:

Precise analyte enrichment is crucial for biosensing, environmental monitoring, and nanomaterial processing.
Current enrichment methods often lack versatility and spatial resolution.

Purpose of the Study:

To introduce a universal, label-free approach for cross-scale analyte enrichment and sensing.
To demonstrate the versatility and efficiency of the new method for diverse targets.

Main Methods:

Optothermal ice-water interface management (OIIM) uses optically guided ice-water interfaces to create tunable nanovessels.
Analyte enrichment is achieved by actively driving targets into confined regions.
Molecular dynamics simulations and fluorescence imaging were used to study solute-interface interactions.

Main Results:

OIIM efficiently enriches diverse analytes, including dyes, particles, nucleotides, proteins, and nanomaterials.
The method supports multisite enrichment, spatial consolidation, and formation of femtoliter microreactors.
OIIM successfully enriches ultrashort nucleic acids, overcoming limitations of conventional methods.

Conclusions:

OIIM provides a flexible, molecular-level optothermal strategy for analyte enrichment and sensing within ice.
This technique enhances analyte concentration and enables advanced applications in various scientific fields.