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Effect of Chaihu Guizhi granules on clinical parameters and vascular endothelial function in patients with stable
Yu Cao1, Sihui Wang2, Menghua He3
1Department of Geriatrics, Yueyang Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Insights
Chaihu Guizhi granules (CHGZ) significantly improved symptoms and vascular endothelial function in stable angina pectoris (SAP) patients. This Chinese herbal medicine shows promise as a safe, beneficial adjuvant therapy for SAP.
Area of Science:
- Cardiology
- Integrative Medicine
- Pharmacology
Background:
- Coronary artery disease (CAD) poses a significant global health burden.
- Endothelial dysfunction is a key predictor of CAD.
- Chinese herbal medicine offers therapeutic potential for CAD patients.
Purpose of the Study:
- To assess the efficacy and safety of Chaihu Guizhi granules (CHGZ) in stable angina pectoris (SAP).
- To investigate CHGZ's mechanism in improving vascular endothelial function.
- To provide evidence for CHGZ's clinical application in SAP.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 90 SAP patients.
- Intervention group received CHGZ with conventional medicine; control group received placebo with conventional medicine for 4 weeks.
- Evaluated angina symptoms, quality of life, cardiac markers, and endothelial function.
Main Results:
- CHGZ group showed significant improvements in angina curative effect and nitroglycerin discontinuation rate compared to placebo.
- CHGZ treatment led to significant reductions in TCM syndrome scores and NT-proBNP levels.
- CHGZ positively impacted endothelial function markers, including nitric oxide (NO) and asymmetric dimethylarginine.
Conclusions:
- CHGZ demonstrates beneficial effects as an adjuvant therapy for SAP.
- CHGZ improves clinical symptoms, quality of life, and vascular endothelial function safely.
- Further research is warranted to elucidate the precise mechanisms of CHGZ's action on endothelial function.
Background:
Coronary artery disease (CAD) is a major cause of health problems and deaths worldwide. Endothelial function is an independent predictor of CAD. Chinese herbal medicine has been proven to effectively improve the clinical symptoms and prognosis of patients with CAD. The purpose of this study was to evaluate the efficacy and safety of Chaihu Guizhi granules in patients with stable angina pectoris (SAP), explore the possible mechanism through which Chaihu Guizhi formula (CHGZ) improves vascular endothelial function, and provide evidence-based medical support for the rational clinical use of CHGZ.
Methods:
In this randomized, double-blind, placebo-controlled study, 90 patients were randomly assigned to the control group or the CHGZ group. The patients in the CHGZ group received conventional Western medicine and CHGZ granules for 4 weeks, while the patients in the placebo group received conventional Western medicine and placebo. The efficacy for angina pectoris, nitroglycerin discontinuation rate, traditional Chinese medicine (TCM) syndrome score, seattle angina questionnaire (SAQ) score, cardiac markers, vascular endothelial function and safety indicators were evaluated before and after the intervention.
Results:
At the end of this study, compared with those in the control group, the curative effect on angina pectoris; the total nitroglycerin discontinuation rate; the total TCM syndrome score; and the scores of several dimensions of the SAQ, B-type natriuretic peptide precursor (NT-proBNP), asymmetric dimethylarginine, endothelial nitric oxide synthase, nitric oxide (NO) and endothelin 1 in CHGZ group were significantly greater (P < .05 or P < .01).
Conclusion:
CHGZ may be a beneficial adjuvant treatment for SAP patients. CHGZ can effectively improve clinical symptoms, quality of life, and vascular endothelial function and is safe. The detailed mechanism through which CHGZ affects vascular endothelial function should be further studied in the future.
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