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Risk for severe refractory Mycoplasma pneumoniae pneumonia complicated with bronchitis obliterans among children

Zhonghua Hu1, Chengchao Fang

  • 1Department of Pediatrics, Linping Branch the Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Medicine
|November 8, 2025
PubMed

Insights

Elevated D-dimer, ferritin, and plastic mucus plugs are key risk factors for severe refractory MP pneumonia complicated by bronchitis obliterans in children. High albumin levels, however, show a protective effect against this severe respiratory complication.

Area of Science:

  • Pediatric Pulmonology
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Severe refractory MP pneumonia (SRMPP) in children can lead to serious complications like bronchitis obliterans.
  • Identifying risk factors for this complication is crucial for timely intervention and improved outcomes.

Purpose of the Study:

  • To determine the independent risk factors associated with the development of bronchitis obliterans in pediatric patients with SRMPP.
  • To identify potential protective factors that may mitigate the risk of this complication.

Main Methods:

  • Retrospective analysis of clinical data from 120 children with SRMPP.
  • Multivariate logistic regression to identify independent risk and protective factors.
  • Receiver operating characteristic (ROC) curve analysis to evaluate predictive values of identified factors.

Main Results:

  • Elevated D-dimer (OR: 2.46), elevated ferritin (OR: 2.93), and plastic mucus plugs (OR: 6.32) were identified as significant independent risk factors for bronchitis obliterans.
  • High serum albumin levels (OR: 0.82) were found to be an independent protective factor.
  • ROC analysis showed predictive values for D-dimer (0.68), ferritin (0.66), albumin (0.72), and plastic mucus plugs (0.70).

Conclusions:

  • Elevated D-dimer, ferritin, and the presence of plastic mucus plugs are significant risk factors for developing bronchitis obliterans in children with SRMPP.
  • Maintaining high serum albumin levels may offer protection against this severe complication.
Keywords:
bronchitis obliteranschildren

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