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Published on: November 14, 2018
Navigating the challenges in pediatric intranasal drug delivery
Xiomara Owen1, Mohammad Hejazi1, Laleh Golshahi1,2
1Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Pediatric intranasal drug delivery offers a noninvasive alternative but faces challenges. An integrated approach optimizing formulations, devices, and techniques for children
Area of Science:
- Pediatric pharmacology
- Drug delivery systems
- Biomedical engineering
Background:
- Pediatric intranasal (IN) drug delivery presents a noninvasive alternative to traditional methods.
- Significant challenges exist due to anatomical variations in children and inconsistent dosing.
- Overcoming these obstacles is crucial for effective pediatric medication administration.
Purpose of the Study:
- To explore technological strategies addressing pediatric drug delivery challenges.
- To review advancements in formulation and device engineering for improved drug deposition and absorption.
- To highlight applications in nose-to-brain delivery and intranasal vaccines.
Main Methods:
- Literature review of studies from January 2015 to December 2025.
- Analysis of technological strategies from Google Scholar and PubMed.
- Focus on formulation, device engineering, and overcoming the nasal mucus barrier.
Main Results:
- Advancements in formulation and device engineering enhance drug deposition and absorption.
- Regional deposition is relevant for nose-to-brain delivery and intranasal vaccines.
- Novel formulation strategies are being developed to address the nasal mucus barrier.
Conclusions:
- The future of pediatric IN delivery requires coordinated advancements in multiple factors.
- Integrating physical and computational models optimizes formulations, devices, and delivery techniques.
- A multifactorial strategy will enable reliable and personalized pediatric therapies.
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