Related Experiment Video
Updated: Jan 6, 2026

Intravenous Injections in Neonatal Mice
Published on: November 11, 2014
How I do it: continuous intraventricular interferon alpha infusion in pediatric patients with subacute sclerosing
Francesco Tengattini1,2, Gabriella Errichiello3,4, Antonio Varone3
1Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia and Spedali Civili Hospital, Brescia, Italy. f.tengattini003@unibs.it.
Background:
Subacute sclerosing panencephalitis (SSPE) is a chronic disease affecting the central nervous system (CNS) because of persistent measles virus (MeV) infection. Among the various treatment available the intraventricular interferon alpha administration demonstrated greater effectiveness.
Method:
In this article is described the step-by-step surgical technique of the positioning of an intraventricular catheter connected to a rechargeable subcutaneous pump. The main surgical steps and the pump settings are illustrated in a supplementary video.
Conclusion:
This surgical management guarantees a continuous drug release improving the therapeutic effect in terms of clinical and neuroradiological outcome and reducing the toxicity profile.
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