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Updated: Jan 11, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Mechanisms of whole-genome doubling in cancer evolution

Connor D McKenney1, Sergi Regot1

  • 1Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Trends in Cancer
|November 8, 2025
PubMed

Keywords:
WGDcytokinesis failureendoreplicationmitotic slippageploidy-specific lethalitytetraploid

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