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Echinocandin-resistant Candida albicans: A case report from Japan
Sayaka Hikida1, Yutaro Akiyama1, Masahiro Ishikane1
1Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan Institute of Health Security, Tokyo, Japan.
Abstract:
Echinocandin-resistant Candida albicans (C. albicans) is a rare but increasing global concern. In Japan, at least three cases had been confirmed by the end of 2015. Mutations in FKS cause echinocandin resistance in Candida species, which is primarily driven by previous echinocandin antifungal use. C. albicans resistance to echinocandins is raising clinicians' concerns globally and could pose a threat to Japan in the near future. The fungus is also an antimicrobial-resistant pathogen, raising awareness of the risk of resistance to prophylactic antifungals. Herein, we report a case of echinocandin-resistant C. albicans at our hospital. Mutations in the FKS gene that cause echinocandin resistance in Candida species have been detected.
Insights
Echinocandin-resistant Candida albicans is a growing global threat. This study reports a case in Japan, highlighting FKS gene mutations as a cause of this dangerous antifungal resistance.
Area of Science:
- Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Echinocandin-resistant Candida albicans (C. albicans) is an emerging global health concern.
- Antifungal resistance, particularly to echinocandins, is increasing worldwide.
- Previous echinocandin antifungal use is a primary driver of resistance.
