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The Pediatric Clinician's Approach for Anxiety, Depression, and Suicide Ideation in Children with Sickle Cell Disease

Robert M Cronin1

  • 1General Internal Medicine, The Ohio State University, 700 Ackerman Road, Ackerman Place, Suite 4000, Columbus, OH 43202, USA.

Pediatric Clinics of North America
|November 9, 2025
PubMed

Insights

Mental health conditions like depression and anxiety are common in sickle cell disease (SCD). Regular screening and evidence-based treatments, including therapy and medication, are crucial for improving patient quality of life and outcomes.

Area of Science:

  • Hematology
  • Psychiatry
  • Pediatrics

Background:

  • Sickle cell disease (SCD) presents complex mental health challenges.
  • Depression and anxiety are prevalent in SCD patients.
  • These conditions negatively impact quality of life, clinical outcomes, and mortality.

Purpose of the Study:

  • To highlight the importance of integrated mental health care in SCD.
  • To emphasize the need for regular screening for depression and anxiety.
  • To outline evidence-based treatment strategies for mental health conditions in SCD.

Main Methods:

  • This review synthesizes current evidence on mental health in SCD.
  • It focuses on screening protocols and treatment modalities.
  • The medical home model is highlighted as a framework for care.

Main Results:

  • Annual screening for depression and anxiety is recommended, starting in adolescence or earlier.
  • Psychotherapy, including cognitive behavioral therapy, is an effective treatment.
  • Pharmacotherapy, such as SSRIs and SNRIs, is also indicated, with options that address neuropathic pain.

Conclusions:

  • Integrated, multidisciplinary mental health care is essential for SCD management.
  • Timely screening and evidence-based interventions can improve patient well-being.
  • Addressing mental health in SCD is critical for overall clinical outcomes and survival.

Keywords:
AnxietyDepressionMental healthSickle cell anemiaSickle cell diseaseSuicidal ideation

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