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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The pre-procedure steps of handwashing include removing jewelry and rolling up sleeves. However, many organizations allow staff to wear wedding rings.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Sustainability and Procedural Dermatology.

Fatima Ali1, Sue Ann Chan2, Viktoria Eleftheriadou3

  • 1Department of Dermatology, King's College Hospital NHS Foundation Trust, London, UK; British Association of Dermatologists Sustainability Subcommittee, London, UK; British Society for Dermatological Surgery Sustainability Subcommittee, London, UK.

Dermatologic Clinics
|November 9, 2025
PubMed
Summary
This summary is machine-generated.

Procedural dermatology significantly impacts the environment. This review explores sustainable practices in skin surgery, energy devices, and cosmetic procedures to reduce the carbon footprint of dermatology.

Keywords:
Cutaneous surgeryEnvironmental sustainabilityMohs micrographic surgeryProcedural dermatologySkin surgery

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Area of Science:

  • Environmental science and dermatology
  • Sustainable healthcare practices

Background:

  • Procedural dermatology includes skin surgery, energy devices, injectables, and chemical peels.
  • These procedures contribute significantly to global carbon emissions, estimated at 2.76 million tons CO2e annually.

Purpose of the Study:

  • To review current literature up to 2025 on sustainable practices in procedural dermatology.
  • To identify methods for reducing the carbon footprint of dermatological procedures.

Main Methods:

  • Narrative review of scientific literature up to 2025.
  • Synthesis of information from guidelines and life cycle analyses.

Main Results:

  • Identification of key areas within procedural dermatology contributing to carbon emissions.
  • Compilation of sustainable practices and their potential impact on reducing environmental footprint.

Conclusions:

  • Procedural dermatology has a substantial environmental impact.
  • Implementing sustainable practices is crucial for mitigating the carbon footprint of dermatological procedures.