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Selpercatinib plus cemiplimab in RET positive medullary thyroid cancer patient with skin cancers

Laura Deborah Locati1,2, Federica Puce1,2, Vito Amoroso3

  • 1Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.

Tumori
|November 10, 2025
PubMed
Abstract

Insights

New combination therapy shows promise for advanced medullary thyroid cancer (MTC). Selpercatinib and cemiplimab were safely combined in a patient with RET-positive MTC and skin cancers, demonstrating a viable treatment option.

Area of Science:

  • Oncology
  • Genetics

Background:

  • Recent advancements in medullary thyroid cancer (MTC) therapeutics are driven by understanding mutations like RET and RAS.
  • New therapies have improved outcomes for advanced and metastatic MTC.

Purpose of the Study:

  • To evaluate the safety and feasibility of combining selpercatinib and cemiplimab in a patient with advanced RET-positive hereditary MTC and secondary skin cancers.

Main Methods:

  • A patient with RET-positive hereditary MTC, previously treated with vandetanib, developed skin cancers and MTC progression.
  • Surgical options for skin cancer were excluded.
  • The patient initiated combination therapy with selpercatinib and cemiplimab for 15 months.

Main Results:

  • The combination therapy was administered at full dosage for 15 months.
  • No new safety concerns or adverse events were reported during the treatment period.

Conclusions:

  • Combination therapy with selpercatinib and cemiplimab is a feasible treatment option for advanced RET-positive MTC.
  • This combination did not introduce new safety signals, suggesting a favorable safety profile.
Keywords:
RETmedullary thyroid cancerselpercatinibskin cancervandetanib

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