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The PI3K/Akt/mTOR Pathway: Immuno-Metabolic Orchestration in IR/MASH-Associated Hepatocellular Carcinoma

Jian Zhao1, Yuehua Zhang2, Zhigong Wei3

  • 1Thoracic Oncology Ward, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.

International Journal of Biological Sciences
|November 10, 2025
PubMed

Keywords:
Hepatocellular CarcinomaInsulin ResistanceMASHMetabolic ReprogrammingPI3K/Akt/mTOR Signaling PathwayTumor Immune Microenvironment

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