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Updated: Jan 11, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Management of Non-Islet Cell Tumor Hypoglycemia Induced by Adrenal Cortical Carcinoma
Yaling Tang1, Oksana Hamidi2, Jessica Abramowitz2
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abstract:
Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome that significantly worsens the prognosis of underlying malignancies. It is characterized by hypoglycemia resulting from ectopic production of insulin-like growth factor 2. NICTH caused by adrenal cortical carcinoma (ACC) is extremely rare. To date, no curative treatment of nonoperable NICTH has been reported. In this report, we describe a case of ACC-induced NICTH that was refractory to multiple treatments for hypoglycemia. It provides diagnostic and treatment approaches for NICTH and emphasizes the limitations of existing medical therapies for NICTH.
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