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Updated: Jan 11, 2026
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Changes in right ventricular function on three-dimensional speckle tracking echocardiography after transcatheter
Mengmeng Ji1,2,3, Wenqian Wu1,2,3, Mingxing Xie1,2,3
1Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Quantitative Imaging in Medicine and Surgery
|November 10, 2025
Summary
Transcatheter pulmonary valve replacement (TPVR) temporarily reduces right ventricular function, but it recovers by 6 months. Preoperative strain predicts post-TPVR RV function and NYHA class.
Area of Science:
- Cardiology
- Echocardiography
- Congenital Heart Disease
Background:
- Pulmonary regurgitation (PR) is a common complication after tetralogy of Fallot (TOF) repair, associated with adverse outcomes.
- Transcatheter pulmonary valve replacement (TPVR) offers a novel treatment for severe PR or mixed pulmonary stenosis and regurgitation.
Purpose of the Study:
- To evaluate changes in right ventricular (RV) function post-TPVR using 2D and 3D speckle tracking echocardiography.
- To identify predictors of RV function and NYHA functional class at 6 months after TPVR.
Main Methods:
- Prospective enrollment of 21 patients undergoing TPVR.
- Acquisition of 2D and 3D RV free wall longitudinal strain (2D-RVFWLS and 3D-RVFWLS) via speckle tracking echocardiography before TPVR, 1 week after, and 6 months after.
Main Results:
- 2D-RVFWLS and 3D-RVFWLS decreased at 1 week post-TPVR but improved to baseline by 6 months.
- Preoperative 2D-RVFWLS and 3D-RVFWLS independently predicted RV function and NYHA class at 6 months.
- Models using 3D-RVFWLS showed comparable or superior predictive ability for RV function and NYHA class compared to 2D-RVFWLS.
Conclusions:
- RV function, assessed by RV free wall longitudinal strain, temporarily declines after TPVR but recovers by 6 months.
- Preoperative RV free wall longitudinal strain is a significant predictor of long-term RV function and clinical outcomes (NYHA class) post-TPVR.
