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Core principles of responsible generative AI usage in research.

Tim-Dorian Knöchel1,2, Konrad J Schweizer3, Oguz A Acar4

  • 1Department of Social and Cultural Psychology, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.

AI and Ethics
|November 10, 2025
PubMed
Summary
This summary is machine-generated.

This study outlines eight core principles for the responsible use of Generative Artificial Intelligence (GenAI) in research. These guidelines aim to ensure ethical and effective integration of AI tools across various scientific disciplines.

Keywords:
EthicsGenerative artificial intelligenceGuidelinesPolicy and regulationResearch integrity

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Area of Science:

  • Artificial Intelligence
  • Scientific Research Ethics
  • Publishing Practices

Background:

  • The rapid advancement of Generative Artificial Intelligence (GenAI) necessitates updated guidelines for responsible research practices.
  • Existing frameworks require adaptation to address the evolving GenAI landscape.
  • A stable set of principles is crucial for navigating GenAI use in research.

Purpose of the Study:

  • To define a stable set of core principles for the responsible application of GenAI in research.
  • To provide a framework applicable across diverse use cases and GenAI technologies.
  • To support researchers, policymakers, and publishers in establishing ethical AI integration.

Main Methods:

  • An anonymised Delphi consensus procedure was employed.
  • A panel of 16 international and multidisciplinary experts participated.
  • Three rounds of independent rating and feedback facilitated consensus.

Main Results:

  • Consensus was reached on eight sequentially ordered principles for responsible GenAI usage.
  • The principles include: Regulations, Data Security, Quality Control, Originality, Bias Mitigation, Accountability, Transparency, and Broader Impact.
  • A checklist was developed for reporting adherence to these principles.

Conclusions:

  • The established principles offer guidance for everyday research involving GenAI.
  • The framework aims to inform the development of specific regulations and policies.
  • Promoting discussion on GenAI use in research is a key objective.