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Updated: May 6, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Chitosan based smart injectable hydrogels for biomedical applications: A comprehensive review.

Qamar Salamat^1,2, Rasoul Moradi^1,3,4, Zahra Nadizadeh⁵

¹NanoBioAnalytical Chemistry Center, Khazar University, Baku, Azerbaijan.

Bioactive Materials

|November 10, 2025

Summary

Chitosan-based smart injectable hydrogels (CS-SIHs) offer advanced drug delivery and tissue engineering solutions. These adaptable materials show great promise for clinical applications, despite facing translation challenges.

Keywords:

Chitosan Injectable hydrogels Tissue engineering Wound healing drug delivery

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Last Updated: May 6, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

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Published on: September 29, 2017

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

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Published on: April 13, 2022

Area of Science:

Biomaterials Science
Regenerative Medicine
Drug Delivery Systems

Background:

Chitosan-based smart injectable hydrogels (CS-SIHs) are versatile platforms due to biocompatibility and biodegradability.
Their responsiveness to stimuli (pH, temperature, ionic strength) enables controlled therapeutic release.
CS-SIHs mimic the extracellular matrix, promoting cell functions crucial for tissue engineering.

Purpose of the Study:

To review novel CS-SIH formulations and their therapeutic applications.
To analyze recent preclinical and translational studies of CS-SIHs.
To explore challenges and opportunities for clinical translation of CS-SIHs.

Main Methods:

Systematic integration of physicochemical properties and intelligent response mechanisms.
Analysis of various crosslinking strategies for CS-SIH development.
Review of biomedical applications in bone regeneration, cartilage repair, and wound healing.

Main Results:

CS-SIHs demonstrate potential for enhanced bioactivity, mechanical integrity, and environmental adaptability.
Encapsulation of diverse therapeutic agents (proteins, nucleic acids, small molecules) facilitates minimally invasive delivery.
Significant progress in preclinical studies highlights the therapeutic efficacy of CS-SIHs.

Conclusions:

CS-SIHs represent a promising frontier in biomedical engineering for advanced therapies.
Further research is needed to overcome clinical translation hurdles like regulatory issues and scalability.
This review provides a framework for future development of intelligent hydrogel systems.