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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Blinding01:11

Blinding

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Crossover Experiments01:16

Crossover Experiments

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Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
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Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Creative Thinking01:25

Creative Thinking

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Creative thinking encompasses innovative and unconventional methods for addressing challenges, often leading to groundbreaking solutions. Instead of focusing solely on enhancing existing systems, such as increasing smartphone battery capacity, creative thinking might inspire advancements like energy-efficient batteries or processors that minimize power consumption. This multidimensional approach underscores the importance of exploring novel pathways to innovation.
Divergent thinking is the...
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Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
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Revolutionizing patient recruitment experience in trials using the design-thinking framework.

Shilpa Patkar1, Jeroze Dalal1

  • 1General Medicines, Chief Patient Officer (CPO) Organization, GlaxoSmithKline, Mumbai, Maharashtra, India.

Perspectives in Clinical Research
|November 10, 2025
PubMed
Summary

Design thinking offers a human-centered approach to improve patient recruitment in clinical trials. This strategy aims to enhance trial enrollment by understanding and addressing patient needs, ultimately benefiting healthcare innovation.

Keywords:
Clinical trialsdesign thinkinginnovationinvestigatorspatient centricitypatient experiencepatient recruitmentrecruitment strategiessponsors

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Area of Science:

  • Healthcare innovation
  • Clinical trial management
  • Patient engagement

Background:

  • Healthcare delivery faces challenges in efficiency and effectiveness.
  • Clinical trials are crucial for medical advancement but struggle with patient recruitment.
  • Existing recruitment strategies have not fully resolved issues like low enrollment and high screen failure rates.

Purpose of the Study:

  • To explore the potential of design thinking as a solution for patient recruitment challenges in clinical trials.
  • To examine how design thinking principles can improve clinical trial enrollment and patient experience.
  • To provide insights for sponsors, patients, sites, and contract research organizations (CROs) on enhancing trial participation.

Main Methods:

  • The article reviews the principles and processes of design thinking.
  • It analyzes how a human-centered approach can address patient recruitment barriers.
  • The study discusses the benefits of design thinking in creating effective recruitment strategies.

Main Results:

  • Design thinking provides novel insights into patient needs and behaviors.
  • It can lead to more engaging and effective patient recruitment strategies.
  • Humanizing the patient trial experience is key to enhancing enrollment.

Conclusions:

  • Design thinking is a promising approach to overcome persistent challenges in clinical trial patient recruitment.
  • Implementing design thinking can lead to more efficient, cost-effective, and successful clinical trials.
  • This methodology has the potential to transform the clinical trial landscape by prioritizing the patient experience.