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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Combined Effects of Drugs: Synergism01:27

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

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Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
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Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Related Experiment Video

Updated: Jan 11, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Reducing the Risk of Targeted Multidrug-Resistant Organism Transmission.

Sheila D Shipley1

  • 1Veterans Health Administration, Kansas City, MO, USA.

Journal of Infection Prevention
|November 10, 2025
PubMed
Summary

Implementing Centers for Disease Control and Prevention (CDC) guidelines significantly reduced the time to initiate transmission-based precautions (TBPs) for patients with multidrug-resistant organisms (MDROs), enhancing patient safety.

Keywords:
Multidrug-resistant organismevidence-based practiceinfection controlinfection preventiontransmission-based precautions

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Area of Science:

  • Healthcare-associated infections
  • Infection control
  • Epidemiology

Background:

  • Preventing multidrug-resistant organism (MDRO) transmission in hospitals is difficult due to infection control practice gaps.
  • These gaps increase transmission risk and compromise patient safety.

Purpose of the Study:

  • To evaluate the impact of implementing two CDC guidelines on timely initiation of transmission-based precautions (TBPs).
  • Focus on inpatients with existing or historical multidrug-resistant organism (MDRO) colonization or infection.

Main Methods:

  • Quantitative methodology with a quasi-experimental design.
  • Pre- and post-implementation data analyzed using independent samples t-test.
  • Assessed time to initiation of transmission-based precautions (TBPs).

Main Results:

  • Implementation of CDC guidelines significantly reduced TBPs initiation time by a mean of 16.32 hours.
  • The reduction was statistically significant (t(23.21) = 2.91, p = .008).
  • This indicates both statistical and clinical significance in reducing transmission risk.

Conclusions:

  • The intervention positively impacted time to TBPs initiation.
  • Translating CDC guidelines into nursing practice can improve MDRO patient identification.
  • This leads to reduced transmission risk in healthcare settings.