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The Pathophysiology of Coronary Artery Disease

Mark Staroselsky1, Angelo Materia2, Ramses R Damera1

  • 1Department of Cardiology, Nassau University Medical Center, East Meadow, New York.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|November 10, 2025
PubMed

Insights

This review details the pathophysiology of coronary artery disease (CAD), a major cardiovascular disease. Understanding CAD mechanisms aids clinicians in patient management and drives future therapeutic advancements.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Internal Medicine

Background:

  • Cardiovascular disease (CVD) is a leading global cause of morbidity and mortality.
  • Coronary artery disease (CAD) is a significant contributor to the overall burden of CVD.
  • Effective management of CAD necessitates a deep understanding of its underlying pathophysiological processes.

Purpose of the Study:

  • To review and elucidate the key pathophysiological mechanisms of coronary artery disease (CAD).
  • To provide clinicians with a foundational understanding of CAD pathophysiology to enhance patient care.
  • To inform future research and advancements in the treatment of CAD.

Main Methods:

  • This review synthesizes current literature on the pathophysiology of CAD.
  • Key pathophysiological pathways and molecular mechanisms are discussed.
  • Clinical implications of these mechanisms are explored.

Main Results:

  • A comprehensive overview of CAD pathophysiology is presented.
  • The review highlights the multifactorial nature of CAD development and progression.
  • Understanding these mechanisms is crucial for targeted therapeutic strategies.

Conclusions:

  • A thorough grasp of CAD pathophysiology is essential for effective clinical decision-making.
  • This knowledge facilitates the development of novel treatment approaches for CAD.
  • Continued research into CAD mechanisms promises improved patient outcomes and reduced disease burden.

Keywords:
coronary artery diseasepathophysiologyplaque formationtargeted therapies

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