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Acute Undifferentiated Leukemia Presented With Mediastinal Sarcoma
Hala Alsoukhni1, Dima Al-Dabbas1, Mohammad Masalha1
1Laboratory Department, Military Cancer Center, Amman, Jordan.
Journal of Hematology
|November 10, 2025
Summary
Acute undifferentiated leukemia (AUL) is a rare cancer where leukemia cells lack myeloid or lymphoid lineage. This case highlights the diagnostic challenges and need for comprehensive immunophenotyping for accurate AUL diagnosis.
Area of Science:
- Hematology
- Oncology
- Immunophenotyping
Background:
- Acute undifferentiated leukemia (AUL) is a rare and aggressive leukemia characterized by blasts lacking myeloid or lymphoid lineage commitment.
- It is classified under acute leukemias of ambiguous lineage (ALAL) by the World Health Organization (WHO).
- AUL is associated with a poor prognosis, necessitating accurate and timely diagnosis.

