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Next-Generation Nanomaterials in Biology: From Tissue Regeneration to Targeted Cancer Therapy
Debyashreeta Barik1, V Badireenath Konkimalla1,2
1School of Biological Sciences, National Institute of Science Education and Research (NISER), HBNI, Jatni, India.
IUBMB Life
|November 10, 2025
Summary
Nanomaterials offer dual roles in tissue regeneration and cancer therapy by mimicking natural cues and enabling targeted drug delivery. Future nanomedicine aims for intelligent materials that precisely control healing or destruction for personalized healthcare.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Regenerative Medicine
- Oncology
Background:
- Nanotechnology advancements enable novel biomedical applications.
- Nanomaterials possess programmable and multifunctional properties.
- Dual roles in tissue regeneration and cancer therapy are explored.
Purpose of the Study:
- Review the dual applications of nanomaterials in tissue regeneration and cancer therapy.
- Highlight the programmable and multifunctional nature of nanomaterials.
- Discuss future directions in nanomedicine.
Main Methods:
- Exploration of nanostructured scaffolds and cell-instructive surfaces for tissue engineering.
- Analysis of smart nanocarriers exploiting tumor microenvironmental triggers for drug delivery.
- Review of next-generation platforms with stimuli-responsive designs, immune modulation, and mechano-sensitive systems.
Main Results:
- Nanomaterials guide stem cell behavior and promote tissue regeneration.
- Smart nanocarriers enable precise drug delivery by targeting tumor microenvironments.
- Next-generation platforms offer dynamic control over cellular processes.
Conclusions:
- Careful nanoparticle programming is crucial to balance regenerative and oncologic pathways.
- Intelligent, modular nanomaterials can synergize therapeutic, regenerative, and diagnostic capabilities.
- Context-aware nanomaterials pave the way for precision nanomedicine and personalized healthcare.
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