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Updated: Jan 11, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Continuous-Flow Electrochemistry Enables 1,2-Arylheteroarylation of Alkenes
Xiaohan Sun1, Fantao Meng1, Kun Xu1
1College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, People's Republic of China.
Abstract:
Despite its potential, the radical-mediated 1,2-arylheteroarylation of alkenes for constructing valuable 1,2-arylheteroaryl ethane motifs remains underdeveloped. We herein report an alternative continuous-flow electrochemical approach using alkenes, aryl bromides, and cyanopyridines as coupling partners. This method eliminates the need for sacrificial anodes, catalysts, or chemical oxidants, requires minimal electrolyte, and achieves high regioselectivity. Its utility is underscored by successful applications in the late-stage functionalization of bioactive molecules.
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