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Related Concept Videos

Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

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The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
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External Anatomy of the Kidney01:21

External Anatomy of the Kidney

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The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

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Dissecting Normal and Abnormal Human Kidney Development Using Multiomics.

Luna S Klomp1, Lampros Mavrommatis2, Fanny O Arcolino1,3

  • 1Department of Pediatric Nephrology, Emma Children's Hospital - Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.

Journal of the American Society of Nephrology : JASN
|November 10, 2025
PubMed
Summary
This summary is machine-generated.

Multi-omics approaches offer new insights into congenital kidney anomalies, improving diagnosis and treatment. Integrating molecular data transforms understanding of kidney development and disease for better patient outcomes.

Keywords:
cell biology and structuregenetic diseases and developmentkidney developmentmetabolomicspediatric nephrologyproteomicsrenal development

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Area of Science:

  • Developmental Biology
  • Genetics
  • Genomics
  • Proteomics
  • Metabolomics

Background:

  • Congenital kidney anomalies often lead to chronic kidney disease (CKD) with poor prognostication.
  • Understanding the genetic basis and biological impact of variants on kidney development is limited.
  • Current diagnostic and therapeutic interventions for congenital kidney anomalies are insufficient.

Purpose of the Study:

  • To review multi-omics approaches for understanding congenital kidney anomalies.
  • To explore the application of transcriptomics, epigenomics, proteomics, and metabolomics in kidney development and disease.
  • To discuss the potential of multi-omics for precision diagnostics and therapies.

Main Methods:

  • Review of single-cell and spatial multi-omics techniques.
  • Analysis of molecular data including transcriptomics, epigenomics, proteomics, and metabolomics.
  • Discussion of technical capabilities and challenges in spatial mapping of kidney development.

Main Results:

  • Multi-omics enables deeper biological understanding of congenital kidney anomalies.
  • Integration of molecular insights can clarify genetic and non-genetic disease mechanisms.
  • Case studies demonstrate the utility of multi-omics in experimental design.

Conclusions:

  • Multi-omics approaches hold promise for precise diagnosis and prognostication of congenital kidney anomalies.
  • Integrating molecular data can advance understanding of kidney disease mechanisms.
  • Multi-omics has the potential to revolutionize treatments for congenital kidney anomalies, improving patient care.