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Artificial Intelligence and Multiple Sclerosis: Past, Present, and Future
Moein Amin1, Kunio Nakamura2, Daniel Ontaneda1
1Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, Ohio, United States.
Seminars in Neurology
|November 10, 2025
Summary
Artificial intelligence and machine learning offer significant potential for improving multiple sclerosis (MS) care, from diagnosis to patient monitoring. This review explores AI
Area of Science:
- Neurology
- Medical Informatics
- Artificial Intelligence
Background:
- Multiple sclerosis (MS) management presents complex challenges.
- The integration of Artificial Intelligence (AI) and Machine Learning (ML) is emerging as a transformative force in healthcare.
- AI and ML offer novel approaches to analyze complex datasets in neurological disorders.
Purpose of the Study:
- To review the historical context, current applications, and future prospects of AI and ML in multiple sclerosis (MS).
- To highlight AI's potential in addressing critical challenges in MS management.
- To discuss the implications of AI for clinical decision-making and patient care in MS.
Main Methods:
- Comprehensive literature review of AI and ML applications in multiple sclerosis.
- Analysis of AI's role in diagnosis, treatment individualization, prognostication, and patient monitoring.
- Exploration of data-driven insights from large and high-dimensional datasets.
Main Results:
- AI demonstrates significant potential for early and accurate diagnosis of MS.
- AI can facilitate individualized treatment strategies and improve patient prognostication.
- AI tools promise efficient patient monitoring and enhanced clinical decision-making.
Conclusions:
- AI and ML are poised to revolutionize multiple sclerosis care by providing deeper insights and augmenting clinical practice.
- Addressing limitations and challenges is crucial for the successful implementation of AI in MS research and clinical settings.
- The future of MS management will likely involve sophisticated AI-driven tools for comprehensive patient care.
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