Related Experiment Video
Updated: Jan 11, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
Molecular pathology of microRNA-339 during tumor progression
Iman Akhlaghipour1, Negin Taghehchian1, Meysam Moghbeli2
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Cancer, as one of the main causes of human deaths, has an adverse effect on the quality of life in cancer patients. Despite many advances in diagnostic and therapeutic methods, there is still a poor prognosis in cancer patients that can be associated with the late tumor diagnosis. Therefore, investigating the molecular pathology of cancer can help to introduce early diagnostic markers. MicroRNAs (miRNAs) have key roles in regulation of cell proliferation, migration, and apoptosis. Deregulations of miRNAs have been widely reported in various cancers. Regarding the high stability of miRNAs in body fluids, they can be used as the non-invasive diagnostic markers in tumor screening programs and early detection. Considering the aberrant expression of miR-339 in a wide range of tumors, we discussed the role of miR-339 during tumor progressions. MiR-339 mainly functions as a tumor suppressor by the modulation of apoptosis, transcription factors, and signaling pathways. This review can be an effective step towards suggesting miR-339 as a therapeutic target and diagnostic marker in cancer patients.
More Related Videos
09:45An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
Published on: May 21, 2019
09:06MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
Related Concept Videos
MicroRNAs
MicroRNAs
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
lncRNA - Long Non-coding RNAs
Abnormal Proliferation