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Related Experiment Video

Updated: Jan 11, 2026

A High-Throughput Platform for Culture and 3D Imaging of Organoids
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Multiscale Construction, Evaluation, and Application of Organoids.

Wanting Ma1,2,3, Zhenglin Dong4, Zhu'anzhen Zheng1,2,3

  • 1MedEng-X Institutes, Shanghai University, Shanghai, 200444, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 11, 2025
PubMed
Summary

This study introduces a multi-scale framework for organoid technology, enhancing construction, evaluation, and application. Artificial intelligence (AI) further optimizes organoid research for biomedical and therapeutic advancements.

Keywords:
applicationartificial intelligence (AI)evaluationmulti‐scale constructionorganoids

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Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Organoids are crucial models in research and biomedical applications.
  • Current organoid technology faces challenges in construction, evaluation, and translation.

Purpose of the Study:

  • To present a comprehensive multi-scale perspective on organoid technology.
  • To advance organoid research and its biomedical applications through optimized methodologies.
  • To explore the potential of artificial intelligence (AI) in organoid research.

Main Methods:

  • Dual-scale construction integrating micro- and macro-scale strategies.
  • Four-dimensional evaluation assessing performance from molecular to in vivo levels.
  • Triple-point application analysis across basic research, preclinical studies, and clinical use.

Main Results:

  • Optimized material selection and spatial organization enhance organoid biological fidelity.
  • Systematic evaluation ensures robust characterization of functional performance and stability.
  • AI integration streamlines construction, analysis, and assessment for improved efficiency.

Conclusions:

  • The multi-scale approach provides critical insights for optimizing organoid technology.
  • Refined methodologies and AI integration facilitate clinical translation and therapeutic applications.
  • Organoid technology holds significant promise for disease modeling, drug screening, and regenerative medicine.