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Related Experiment Video

Updated: Jan 11, 2026

Microwave Photonics Systems Based on Whispering-gallery-mode Resonators
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Solid-state low-threshold hemispherical shell-shaped protein whispering-gallery mode laser.

Zibo Meng, Jiajia Meng, Gaoshang Li

    Optics Express
    |November 11, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed a novel protein-based whispering-gallery mode (WGM) laser using silk fibroin and mCherry protein. This biodegradable biosensor shows tunable wavelengths and a low lasing threshold, paving the way for advanced optical devices.

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    Area of Science:

    • Biophotonics
    • Materials Science
    • Biotechnology

    Background:

    • Protein-based whispering-gallery mode (WGM) lasers offer potential for biosensing due to their inherent biodegradability, biocompatibility, and non-toxicity.
    • Developing stable and efficient protein-based optical devices is crucial for advancing biosensing technologies.

    Purpose of the Study:

    • To report a novel solid-state hemispherical shell-shaped protein WGM laser (hspWGM laser).
    • To demonstrate the tunable wavelength characteristics and low lasing threshold of the protein WGM laser.
    • To lay the foundation for biodegradable, protein-based biosensors and implantable optical devices.

    Main Methods:

    • Fabrication of hemispherical silk fibroin shells on glass substrates.
    • Coating the silk fibroin shells with red fluorescent protein mCherry.
    • Characterization of lasing properties, including threshold and wavelength tunability.

    Main Results:

    • The hspWGM laser (∼1.5 mm diameter) demonstrated stable lasing performance.
    • The device exhibited short-term room-temperature storage stability.
    • A low lasing threshold of 10.17 µJ/mm² was achieved.
    • Central wavelength characteristics were successfully tuned by adjusting device geometry.

    Conclusions:

    • The developed protein-based WGM laser is a promising platform for biodegradable biosensing applications.
    • The tunable wavelength feature allows for customization in various optical sensing scenarios.
    • This work supports the development of advanced, biocompatible implantable optical devices.