Related Experiment Video
Updated: Jan 11, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
Targeting the innate immune system in treating hepatitis B: prospects for functional cure
Karen Cheuk-Ying Ho1, Rex Wan-Hin Hui1, Wai-Kay Seto1,2
1Department of Medicine, Queen Mary Hospital, The University of Hong Kong, China.
Achieving a functional cure for chronic hepatitis B (CHB) is difficult. Novel therapies targeting the hepatitis B virus (HBV) life cycle and innate immune evasion are emerging to improve CHB treatment outcomes.
Area of Science:
- Hepatology
- Immunology
- Virology
Background:
- Chronic hepatitis B (CHB) is a major global health issue.
- Current treatments like NUCs and Peg-IFNα have limitations in achieving functional cure.
- Hepatitis B virus (HBV) evades the host innate immune system, leading to chronic infection.
Purpose of the Study:
- To review the interaction between the HBV life cycle and the host innate immune system.
- To discuss novel therapeutic agents targeting innate immunity for CHB functional cure.
- To highlight emerging strategies for CHB management.
Main Methods:
- Comprehensive literature review on HBV-host innate immunity interactions.
- Analysis of novel therapeutic agents targeting innate immune evasion strategies.
- Evaluation of therapies including RIG-I agonists, TLR agonists, interferons, siRNAs, and antisense oligonucleotides.
Main Results:
- HBV employs mechanisms to evade host innate immunity, contributing to chronicity.
- Novel agents like RIG-I agonists and TLR agonists directly target HBV evasion.
- siRNAs and antisense oligonucleotides show potential beyond antigen knockdown, impacting innate immunity.
Conclusions:
- Understanding HBV's interaction with innate immunity is key to developing functional cure strategies.
- Emerging therapies targeting innate immunity offer new hope for CHB treatment.
- Combination strategies and ongoing research are anticipated to advance CHB management.
More Related Videos
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Related Concept Videos
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...