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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
Chronic Hepatitis B Infection: Patient Guidance
Lung-Yi Mak1, Jimmy Che-To Lai2, Ken Liu3
1Department of Medicine, School of Clinical Medicine, The Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chronic hepatitis B (CHB) affects millions globally, often undiagnosed. Early assessment and management, including lifestyle changes and available treatments, are crucial for preventing liver damage and cancer.
Area of Science:
- Hepatology
- Public Health
- Patient Education
Background:
- Chronic hepatitis B (CHB) is a major global cause of cirrhosis and liver cancer.
- Awareness of CHB infection is low, with less than 20% of infected individuals knowing their status.
- Many infected individuals do not receive adequate assessment and management for CHB.
Purpose of the Study:
- To provide patient guidance for individuals at risk of or living with chronic hepatitis B.
- To summarize updated knowledge on CHB assessment, management, and treatment.
- To empower patients with CHB to actively participate in their healthcare.
Main Methods:
- Development of a patient guidance document through collaboration with clinicians, scientists, patients, and patient representatives.
- Summarization of current scientific knowledge and clinical recommendations for CHB.
- Inclusion of essential measures for CHB management and prevention of transmission.
Main Results:
- Highlights the availability of safe and effective treatments for CHB in many regions.
- Recommends essential measures including lifestyle adjustments, coinfection screening, comorbidity management, fibrosis assessment, HBV transmission prevention, and liver cancer surveillance.
- Notes recent advancements in CHB treatment paradigms and new drug development.
Conclusions:
- Increased patient understanding of CHB can lead to more active participation in disease management.
- Timely assessment and management are vital for individuals with CHB to prevent complications like cirrhosis and hepatocellular carcinoma.
- This guidance aims to inform and empower individuals affected by chronic hepatitis B.
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